Vertiefungskurs Combinatorial Chemistry

Sommersemester 2000


Some general guidelines designed to help you prepare for the final

-  It is not important that you remember the names of investigators, the exact size of libraries, or memorize the exact structures of compounds.
-  What you should know is principles of combinatorial chemistry and the syntheses we discussed.
-  For example, you should know how many compounds a peptide library with n variable residues and N building blocks has, if this library is prepared by split-and-pool synthesis; you should know what a polystyrene solid support is, and you should know that SELEX experiments are performed with RNA.
-  A few details you are expected to know:

(1)  Concept of parallel synthesis of individual compounds
(2)  Starting materials and products for the synthesis of a tetraphenylporphyrin library
(3)  The Ugi Reaction
(4)  The basics of split-and-pool synthesis and selection of beads
(5)  Encoding with tags that can be read out via GC
(6)  The most important types of solid supports
(7)  The basics of peptide synthesis using Boc-protected amino acids, the concept of phage display
(8)  The four key steps of the assembly of DNA on solid support, the basics of the SELEX technique
(9)  The principles of thermographic screening for catalysts and one glycosylation reaction
(10)  The synthesis of a simple benzodiazepine on solid support
(11)  Basics of the synthesis of vancomycin