CR, May 4, 2001

Combinatorial Chemistry


Outline for today's lecture
 
 

Competitive, mixed building block reactions
 
 

1. Synthesis of tetraphenylporphyrin libraries via mixed aldehyde Rothemund cyclizations

2. Purification of crude libraries with solid phase-bound quenching reagents

3. Obtaining reactivity data via mixed component reactions
 
 

Key references:

1. Berlin et al. Biotechn. Bioeng.: Combin. Chem. 1998, 61, 107-118.
2. Booth & Hodges, J. Am. Chem. Soc. 1997, 119, 4882-4886.
3. Gerritz et al., J. Am. Chem. Soc. 2001, 122, 6357-6363.