CR, July 6, 2001

Combinatorial Chemistry

Outline for today's lecture
 
 

Benzodiazepine Libraries
 

1. Introduction to benzodiazepine-based drugs

2. Synthesis of benzodiazepines on solid support

3. Fluorides of Fmoc-amino acids as activated building blocks

4. Benzodiazepine libraries

5. Screening benzodiazepine libraries for compounds with biological activity
 

key references

1. Bunin, B.A.; Ellman, J.A. J. Am. Chem. Soc. 1992, 114, 10997-10998

2. Boojamra, C.G.; Burow, K.M.; Thompson, L.A.; Ellman, J.A. J. Org. Chem. 1997, 62, 1240-1256.

3. Bunin, B.A.; Plunkett, M.J.; Ellman, J.A. Proc. Natl. Acad. Sci. USA 1994, 91, 4708-4712