CR, June 8, 2001

Combinatorial Chemistry

Outline for today's lecture




Peptide Synthesis, Phage Display
 

1. Amino acid building blocks

2. Immobilization on the solid support

3. Activation of carboxylic acid

4. Deprotection reactions
 

5. Introduction to phage display
 

key references

1. Synthesis notes in NovaBiochem catalog.

2. Smith, G.P.; Petrenko, V.A. Chem. Rev. 1997, 97, 391-410.

3. Schumacher, T.N.M.; Mayr, L.M.; Minor, D.L.; Milhollen, M.A.; Burgess, M.W.; Kim, P.S. Science 1996, 271, 1854-1857.