CR, May 11, 2001

Combinatorial Chemistry

Outline for today's lecture


Competitive, mixed building block reactions, ... continued

4. Relative reactivities of amino acid and carboxylic acid building blocks

Multiple-Component Reactions

1. Overview over multiple-component condensation reactions

2. The three component Passerini Reaction

3. The four component Ugi Reaction or 4 component condensation (4CC)

key references

1. Ostresh, J.M.; Winkle, J.H.; Hamashin, V.T.; Houghten, R.A. Biopolymers 1994, 34, 1681-1697.

2. Armstrong, R.W.; Combs, A.P.; Tempest, P.A.; Brown, S.D.; Keating, T.A. , Acc. Chem. Res. 1996, 29, 123-131.