CR, July 13, 2001

Combinatorial Chemistry


Outline for today's lecture
 

Vancomycin Libraries

1. Introduction to vancomycin and cell walls of bacteria

2. Synthesis of the invariant core of the receptor

3. Construction of libraries on solid support

4. Panning with fluorophore-labeled ligand

5. Binding selectivities of receptors

           -  course evaluations  -
 
 

key reference

1. Xu, R.; Greiveldinger, G.; Marenus, L.E.; Cooper, A.; Ellman, J.A. J. Am. Chem. Soc. 1999, 121, 4898-4899 and supporting information.

related references

2. Evans, D.A. et al., Angew. Chem. 1998, 110, 2864 ff.

3. Nicolaou, K.C. et al. Angew. Chem. 1998, 110, 2872 ff.