CR, May 25, 2001

Combinatorial Chemistry

Outline for today's lecture

Encoding and Instrumentation

1. Labeling beads with fragments of the oligomers synthesized (partial capping)

2. Labeling containers containing the resin bearing the compound with EEPROM tags

3. Labeling beads with GC-readable chemical tags that constitute a binary code.

key references

1. Youngquist, R.S.; Fuentes, G.R.; Lacey, M.P.; Keough, T. J. Am. Chem. Soc. 1995, 117, 3900-3906.

2. Nicolaou, K.C.; Xiao, X.-Y.; Parandoosh, Z.; Seneyei, A.; Nova, M.P. Angew. Chem. Int. Ed. Engl. 1995, 34, 2289-2291.

3. Ohlmeyer, M.H.J. et al. & Still, W.C.  Proc. Natl. Acad. Sci. USA 1993, 90, 10922-10926.