CR, June 29, 2001
Combinatorial Chemistry

Outline for today's lecture



Oligosaccharide Libraries, Catalyst Selection, Dynamic Libraries
 

1. Synthesis of an oligosaccharide library and selection for lectin binding

2. Synthesis and screening for acyl transfer catalysts

3. Synthesis and screening for transition metal allylation catalysts

4. Introduction to dynamic combinatorial libraries
 

key references

1. Lin, et al. & Kahne, D. Science 1996, 274, 1520-1522.

2. Taylor, S.J.; Morken, J.P. Science 1998, 280, 267-270.

3. Lavastre, O.; Morken, J.P. Angew. Chem. 1999, 111, 3357-3359.

4. Cousins, Poulsen & Sanders Curr. Opin. Chem. Biol. 2000, 4, 270-279.