Vertiefungskurs Kombinatorische Chemie
Partial Credit Scheme Final
Please note that both point deductions and points obtained for a
certain partial answer are being listed.
Aufgabe 1. (a) and (b) 3 points each for correct number, no points for incorrect numbers; (c) 4 points for correct answer, -2 points, if "m" and "n" were mixed up.
Aufgabe 2. 10 points for correct answer; 3 points for alternative answer that is greatly inferior. No answer, no points.
Aufgabe 3. (a) 14 points for correct answer, -1 point each for incorrect labeling of reaction arrows, missing charge on a tetrasubstituted nitrogen, missing protecting group or support that leads to low level side reaction, or incorrect order of reagents on arrows, -2 points for missing protecting group or solid support that leads to a major side reaction; (b) 9 points total (3x3) for correct answers, -1 point for a building block that is unstable, -2 points for unspecific answer that leaves open the nature of the residue; -2 points for an answer consisting of one general structure only.
Aufgabe 4. 10 points for correct answer; -2 points for a dihydro-derivative of the oxazolone that forms, 5 points for the chloride structure and a correct statement on its stability.
Aufgabe 5. 10 points for correct answer; -2 points for every minor error in the statement.
Aufgabe 6. (a) 10 points for correct answer; -1 point for minor error, -2 points for moderately problematic error in the structure. 5 points for a general structure without the backbone. (b) 5 points for correct answer, -2 points for not drawing or mentioning styrene, 1 point total for an unrelated crosslinking scheme.
Aufgabe 7. 10 points for correct answer, -4 points for isonitrile, -6 points for hydrolysis of linkage.
Aufgabe 8. 12 points for correct answer, 3 points for each correct correlation of reaction site and reaction; -2 points, if Schiff base formation was proposed for site (3), -1 point, if acylation was proposed for site (1).
Aufgabe 9. 10 points for correct answer; -3 points for
every error in an otherwise correct answer.
Maximal erreichte Punktzahl: 86
Scheine: Der Kurs ist bestandenen nach bestandener Klausur,
Absolvierung des Praktikums und Abgabe eines akzeptablen Abschlussberichtes.