CR, July 21, 2001

**Vertiefungskurs Kombinatorische Chemie**

Sommersemester 2001

**Partial Credit Scheme Final**

*Please note that both point deductions and points obtained for a
certain partial answer are being listed.*

**Aufgabe 1**. (a) and (b) 3 points each for correct number,
no points for incorrect numbers; (c) 4 points for correct answer, -2 points,
if "m" and "n" were mixed up.

**Aufgabe 2**. 10 points for correct answer; 3 points for alternative
answer that is greatly inferior. No answer, no points.

**Aufgabe 3**. (a) 14 points for correct answer, -1 point
each for incorrect labeling of reaction arrows, missing charge on a tetrasubstituted
nitrogen, missing protecting group or support that leads to low level side
reaction, or incorrect order of reagents on arrows, -2 points for missing
protecting group or solid support that leads to a major side reaction;
(b) 9 points total (3x3) for correct answers, -1 point for a building block
that is unstable, -2 points for unspecific answer that leaves open the
nature of the residue; -2 points for an answer consisting of one general
structure only.

**Aufgabe 4**. 10 points for correct answer; -2 points for
a dihydro-derivative of the oxazolone that forms, 5 points for the chloride
structure and a correct statement on its stability.

**Aufgabe 5**. 10 points for correct answer; -2 points for
every minor error in the statement.

**Aufgabe 6**. (a) 10 points for correct answer; -1 point for
minor error, -2 points for moderately problematic error in the structure.
5 points for a general structure without the backbone. (b) 5 points
for correct answer, -2 points for not drawing or mentioning styrene, 1
point total for an unrelated crosslinking scheme.

**Aufgabe 7**. 10 points for correct answer, -4 points for
isonitrile, -6 points for hydrolysis of linkage.

**Aufgabe 8**. 12 points for correct answer, 3 points for each
correct correlation of reaction site and reaction; -2 points, if Schiff
base formation was proposed for site (3), -1 point, if acylation was proposed
for site (1).

**Aufgabe 9**. 10 points for correct answer; -3 points for
every error in an otherwise correct answer.

**Maximal erreichte Punktzahl**: 86

**Scheine**: Der Kurs ist bestandenen nach bestandener Klausur,
Absolvierung des Praktikums und Abgabe eines akzeptablen Abschlussberichtes.