CR, February 7, 2001
Nucleic Acids Chemistry
Outline of Today's Lecture

RNA Interference

1. Brief history of RNAi, Quelling, or Posttranscriptional Silencing
2. Studies in C. elegans
3. Fate of dsRNA injected into organisms - Search for proteins required for RNAi
5. Working hypothesis for the mechanism underlying RNAi
6. Presumed role in the suppression of viral infections