CR, December 13, 2000

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Non-Covalent Binding of Small Molecules to DNA and RNA

1.  Electrostatic binding to backbone
     -  Counter ion release
     -  polyamines (spermine and derivatives)
     -  condensation of DNA, folding of tRNA

2.  Intercalators
     -  simple intercalators
     -  anthracycline intercalators
     -  synthetic and natural bisintercalators
     -  nearest neighbor exclusion principle
     -  threading intercalators

3.  Groove binders
     -  Minor groove binders:
          -  netropsin and derivatives
      -  aminoglycosides