CR, November 15, 2000

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Chemical Synthesis of DNA and RNA

1.  Retrosynthetic Considerations

2.  Coupling Methods

 -  Phosphotriester method
 -  H-Phosphonate method
 -  Phosphoramidite method

3.  Solid-Phase Synthesis of DNA

4.  Solid-Phase Synthesis of RNA