CR, January 17, 2001

Nucleic Acids Chemistry

Outline of Today's Lecture

Backbone-Modified Oligonucleotides

1.  Phosphorothioate-linked oligonucleotides
2.  Phosphoramidates as Phosphodiester-Surrogates
3.  Synthesis of Locked Nucleic Acids
4.  Synthesis of PNAs
5.  Synthesis of Dimethylenesulfone-linked RNA Analogs