CR, 25. Oktober 2000

Nucleic Acids Chemistry

Outline of Today's Lecture

DNA and RNA Structure, NMR of Nucleic Acids

1.  Base Pairing

-  Watson-Crick base pairing
-  Hoogsteen base pairing
-  Reverse Hoogsteen base pairing
-  Wobble base pairs

2.  DNA and RNA duplexes

-  A- and B-form duplexes
-  Z-DNA
-  Triple helices, H-DNA

3.  NMR of Nucleic Acids

1H-resonances of nucleotides
-  Assignment of DNA strand based on NOESY cross peaks