CR, December 6, 2000

Nucleic Acids Chemistry
Outline of Today's Lecture

Chemical Reactions of DNA and RNA

1.  Hydrolysis
        Hydrolysis of phosphodiester linkages
        Hydrolysis of glycosidic bond (depurination)
2.  Formation of cyclobutane dimers
        Photochemical cycloaddition
        Cleavage via retro-cycloaddition or excision repair
3.  Alkylation
        Alkylation at N7 of G
        Stand cleavage cause by depurination
4.  Radical-induced damage
        Hydrogen abstraction at the 4'-position
        Strand cleavage caused by oxidative damage