CR, 5. Dezember 2002

Nucleic Acids Chemistry

Outline of Today's Lecture

Non-Covalent Binding of Small Molecules to DNA and RNA

1.  Overview of binding modes to duplexes

2.  Electrostatic binding to the backbone

3.  Intercalators

     -  Structures of intercalators

     -  Nearest neighbor exclusion

4.  Groove binders

     -  Minor groove binders

     -  Sequence selectivity

Reference: Chapter 8 in Blackburn & Gait