CR, 9. Januar 2003

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Synthesis of Modified Oligonucleotides (I)

Introduction to modified oligonucleotides: motivations, approaches

1.   Phosphorothioate-linked oligonucleotides

2.  Phosphoramidates as Phosphodiester-Surrogates

3.  Synthesis of Locked Nucleic Acids