CR, January 23, 2003

Nucleic Acids Chemistry

Outline of Today's Lecture

Antisense Inhibition of Gene Expression

1.  Gene Expression and the Central Dogma of Molecular Biology

2.  Discovery of Antisense Inhibition

3.  Mechanisms of action: steric block and/or RNase H activation

4.  First Generation Antisense Agents

5.  Second Generation Antisense Agents