CR, 24. Oktober 2002

Nucleic Acids Chemistry

Outline of Today's Lecture


DNA and RNA Structure & NMR of Nucleic Acids

1.  Base Pairing

     -  Watson-Crick base pairing

     -  Hoogsteen base pairing

     -  Reverse Hoogsteen base pairing

     -  Wobble base pairs

2.  DNA and RNA duplexes

     -  A- and B-form duplexes

     -  Z-DNA

     -  Triple helices, H-DNA

3.  NMR of Nucleic Acids

     -  1H-resonances of nucleotides

     -  Assignment based on NOESY cross peaks