CR, January 30, 2003

Nucleic Acids Chemistry

Outline of Today's Lecture

RNA Interference

1. Brief history of RNAi, Quelling, or Posttranscriptional Silencing

2. Studies in C. elegans

3. Fate of interfering RNA - proteins required for RNAi

5. Working hypothesis for the mechanisms underlying RNAi

6. Presumed role in the suppression of viral infections and transposons

Reference: May 17 issue of Science 2002, 296, pp. 1260 ff. and preceding litearture cited therein.