CR, 31. Oktober 2002

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Chemical Synthesis of Nucleotides

 
1.  Retrosynthetic Considerations

         -  Need for activation and protecting groups

         -  Fundamental mechanistic considerations
 

2.  Glycosylation Methods

         -  Classical methods

         -  Vorbrüggen glycosylation

         -  Anchimeric effect and stereoselectivity
 

3.  Phosphorylation