CR, June 1, 2005

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Chemical Reactions of DNA and RNA
 

1.  Hydrolysis of DNA and RNA

     -  Hydrolysis of phosphodiesters in RNA

     -  Depurination

2.  Formation of cyclobutane dimers

     -  [2+2]-Cycloaddition

     -  Excision repair

3.  Mutagenic reactions

     -  Reactions with nitrous acid

     -  Alkylation reactions

4.  Radical-induced DNA damage

     -  8-OxoG and its reactions
 

Reference: chapter 7 in Blackburn & Gait