CR, July 6, 2005

Nucleic Acids Chemistry

Outline of Today's Lecture
 

Genotyping Single Nucleotide Polymorphisms and Methylation Patterns
 

1.  Variances in the Genome

     -  Single Nucleotide Polymorphisms

     -  Mutations

2.  Determining SNP Alleles (Genotyping)

     -  Primer extension assay

     -  Taqman Assay

     -  Invader Assay

3.  Haplotypes and the HapMap Project

4.  The Epigenome

     -  Methylation patterns and imprinting

     -  Bisulfite-based methylation assay
 

5.  Course Evaluation