JR, June 15, 2005

Nucleic Acids Chemistry

Outline of Today's Lecture


Synthesis of Modified Oligonucleotides
 

1.  Overview over Backbone-Modified Analogs

     -  Structures

     -  Stability of Duplexes with DNA/RNA
 

2.  Synthesis of Oligonucleotide Analogs
 

2.1  Modified Phosphodiester Linkage

     -  Phosphorothioates

     -  Phosphoramidates
 

2.2  Modified Deoxyribose Ring

     -  Locked Nucleic Acids (LNAs)

     -  Threofuranosyl Nucleic Acids (TNAs)
 

2.3  Oligonucleotides with Amide Linkages

     -  'Peptide' Nucleic Acids (PNAs)

     -  Oligonucleotides with caps