CR, 18. Mai 2005

Nucleic Acids Chemistry

Outline of Today's Lecture

Prebiotic Chemistry of Nucleic Acids and Chemical Replication

1. Hypotheses on the Origin of Life

     -  The Miller experiment

2. Studies on Possible Prebiotic Syntheses

     -  Synthesis of adenine, guanine, cytosine and uracil from simple precursors

     -  Synthesis of sugars and sugar phosphates under potentially prebiotic conditions

     -  Oligomerization of activated nucleotides

     -  Non-enzymatic replication of RNA

     -  Cofactors as fossils of the 'RNA World' -

3. Chemical primer extension studies

 -  Reactions with amino-DNA and nucleotidyl imidazolides

References:  chapter 1 in Voet & Voet,
                    L.E. Orgel, Crit. Rev. Biochem. Mol. Biol. 2004, 39, 99.