CR, 20. April 2005

Nucleic Acids Chemistry

Outline of Today's Lecture
 

1.  Base Pairing

     -  Watson-Crick Base Pairs

     -  Hoogsteen Base Pairs
 

Chemical Synthesis of Nucleosides & Nucleotides
 

2.  Base Introduction Reactions

     -  Classical methods

     -  Vorbrüggen glycosylation

     -  Anchimeric effect and stereoselectivity

     -  Synthesis of C-Nucleosides
 

3.  Nucleotides from Nucleosides
 

     -  Phosphorylation and Phosphitylation
 
 

Reference: first chapter of Vorbrüggen & Ruh-Polenz; chapter 3 in Blackburn & Gait