CR, 25. Mai 2005

Nucleic Acids Chemistry

Outline of Today's Lecture
 
 

Non-Covalent Binding of Small Molecules and Proteins to DNA and RNA
 

1.  Small Molecule Ligands

    - Overview of binding modes to duplexes

    - Electrostatic binding to the backbone

    - Intercalators

    - Groove binders
 

2.  Protein Ligands

    - Alpha-helices in the major groove of dsDNA

    - Transcriptional control: Zinc fingers & leucine zippers

     - Protein-RNA complexes
 

Reference: Chapters 8 & 9 in Blackburn & Gait