CR, 02. November 2006

Nucleic Acids Chemistry


Outline of Today's Lecture
 

1.3  Secondary Structure of DNA and RNA

 -  Duplexes, A-, B-, Z-form

 -   Hydrogen bonding, sugar pucker, helical structure

 -  Triplexes, Hoogsteen base pairing

 -  Quadruplexes, Q-quartetts
 

2. Chemical Synthesis of Nucleosides & Nucleotides

2.1  Base Introduction Reactions

 -  Retrosynthetic considerations

 -  Classical method

 -  Vorbrüggen glycosylation
 

References:

-  Chapter 29 in Voet & Voet
-  Vorbrüggen & Ruh-Polenz, Handbook of Nucleoside Synthesis
-  For quadruplexes, e.g. Parkinson, et al. Nature 2002, 417, 876.