CR, 7. December 2006

Nucleic Acids Chemistry

Outline of Today's Lecture

5. Prebiotic Chemistry, Non-Enzymatic Replication

5.3 Studies on Possible Prebiotic Syntheses

 -  Synthesis of ribose phosphates under potentially prebiotic conditions

 -  Formation of glycolic aldehyde phosphate

 -  Alternative structures to RNA and DNA

       Hexopyranosl nucleic acids

       Pentopyranosl nucleic acids

       Tetrafuranosyl nucleic acids (TNA)

 -  Oligomerization of activated ribonucleotides

5.4 Non-enzymatic replication of RNA and DNA

 -  Primer extension with RNA and amino-DNA primers

References:  Eschenmoser, Hall, Chem. Comm. 2004, 1247.
                    Huang & Ferris, J. Am. Chem. Soc. 2006, 128, 8914.
                    Vogel & Richert, Chem. Comm. 2005, 4922.