CR, 09. November 2006

Nucleic Acids Chemistry

Outline of Today's Lecture
 

2. Chemical Synthesis of Nucleosides & Nucleotides

2.1  Base Introduction Reactions

     -  Classical approaches, quaternization method

     -  Vorbrüggen glycosylation

     -  Anchimeric effect and stereoselectivity

     -  Synthesis of C-Nucleosides

2.2  Nucleotides from Nucleosides

     -  Phosphorylation and Phosphitylation
 

3. Biosynthesis of Nucleotides

3.1  Biosynthesis of inosine 5'-monophosphate

3.2  Conversion of IMP to AMP

3.3  Synthesis of uridine monophosphate
 
 
 

References: -Vorbrüggen & Ruh-Polenz, Handbook of Nucleoside Synthesis
                   - Chapters 28 and 29 in Voet & Voet