CR, January 11, 2007

Nucleic Acids Chemistry

Outline of Today's Lecture

8. Oligonucleotides as Drug Candidates:  Antisense Oligonucleotides, RNA Interference & CpG Oligonucleotides

1. Short Introduction to Antisense Therapy, RNAi and Immunostimulatory DNA

2.  Criteria for and Synthesis of Oligonucleotide Analogs

2.1  Modified Phosphodiester Linkage

     -  Phosphorothioates

     -  Phosphoramidates

2.2  Modified Deoxyribose Ring

     -  Locked Nucleic Acids (LNAs)

2.3  Oligonucleotides with Amide Linkages

     -  'Peptide' Nucleic Acids (PNAs)

     -  Morpholino DNA