CR, December 21, 2006

Nucleic Acids Chemistry


Outline of Today's Lecture
 

7. Chemical Reactions of DNA and RNA
 

7.1  Acidity and Basicity of DNA and RNA

7.2  Hydrolysis of DNA and RNA

     -  Hydrolysis of phosphodiesters in RNA

     -  Depurination

7.3  Formation of cyclobutane dimers

     -  [2+2]-Cycloaddition

     -  Excision repair

7.4  Mutagenic reactions

     -  Reactions with nitrous acid

     -  Alkylation reactions

7.5  Radical-induced DNA damage

     -  8-OxoG and its conversion
 

Reference: Chapter 7 in Blackburn & Gait
                (chapter 8 in 3rd edition)