CR, 30. November 2006

Nucleic Acids Chemistry


Outline of Today's Lecture
 

5. Chemical Synthesis of RNA, Prebiotic Chemistry
 

5.1  Chemical Synthesis of RNA

     -  2'-TBDMS-based method

     -  2'-Fpmp-based method

     -  2'-Orthoester-based method
 

5.2 Hypotheses on the Origin of Life

     -  The Miller experiment

     -  Cofactors as fossils of the 'RNA World'
 

5.3 Studies on Possible Prebiotic Syntheses

     -  Synthesis of adenine from simple precursors

     -  Synthesis of sugars under potentially
        prebiotic conditions
 

References:  Chapter 3 in Blackburn & Gait
                    Chapter 1 in Voet & Voet,
                    Orgel, Crit. Rev. Biochem. Mol. Biol. 2004, 39, 99.