List of Publications


  1. H. Griesser, A. Schwenger, C. Richert, Encapsulating active pharmaceutical ingredients in self-assembling adamantanes with short DNA zippers. ChemMedChem, published online as accepted article, September 15, 2017.

  2. M. Kramer, C. Richert, Enzyme-free ligation of 5'-phosphorylated oligodeoxynucleotides in a DNA nanostructure. Chem. Biodiv. 2017, 14, e1700315. [ Open Access ].
  3. Cover: [ Link]

  4. A. Schwenger, N. Birchall, C. Richert, Solution-phase synthesis of branched oligonucleotides with up to 32 nucleotides and the reversible formation of materials. Eur. J. Org. Chem., published online August 15, 2017, DOI 10.1002/ejoc.201700686

  5. C. Richert, F. Krupp, Encapsulating organic crystals (EnOCs). Synlett 2017, 28, 1763-1766. [Open Access].

  6. P.-E. Alexandre, A. Schwenger, W. Frey, C. Richert, High loading crystals of tetraaryladamantanes and the uptake and release of aromatic hydrocarbons from the gas phase. Chem. Eur. J., 2017, 23, 9018-9021.

  7. R. J. Schwarz, C. Richert, A four-helix bundle DNA nanostructure with binding pockets for pyrimidine nucleotides. Nanoscale, 2017, 9, 7047-7054.

    Back Cover: [ Back cover image]

  8. H. Griesser, M. Bechthold, P. Tremmel, E. Kervio, C. Richert, Amino acid-specific, ribonucleotide-promoted peptide formation in the absence of enzymes. Angew. Chem. Int. Ed. 2017, 56, 1224-1228.

  9. H. Griesser, P. Tremmel, E. Kervio, C. Pfeffer, U.E. Steiner, C. Richert, Ribonucleotides and RNA promote peptide chain growth. Angew. Chem. Int. Ed. 2017, 56, 1219-1223.

  10. A. Schwenger, W. Frey, C. Richert, Reagents with a crystalline coat. Angew. Chem. 2016, 128, 13910-13913; Angew. Chem. Int. Ed. 2016, 55, 13706-13709.

    highlighted by: [S. Ritter, Crystalline coating tames rambunctious reagents, in the September 12, 2016 issue of Chemical & Engineering News]

    Cover:[ Cover image]

  11. E. Kervio, M. Sosson, C. Richert, The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA. Nucleic Acids Res. 2016, 44, 5504-5514.

  12. M. Kalinowski, R. Haug, H. Said, S. Piasecka, M. Kramer, C. Richert, Phosphoramidate ligation of oligonucleotides in nanoscale structures. ChemBioChem 2016, 17, 1150-1155.

  13. S. Vollmer, C. Richert, DNA triplexes that bind several cofactor molecules (cover). Chem. Eur. J. 2015, 21, 18613-18622.

    Cover: [ Cover image and Cover profile]

  14. A. Goeckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. (inside front cover). Org. Biomol. Chem. 2015, 13, 10303 - 10309.

  15. M. Jauker, H. Griesser, C. Richert, Spontaneous formation of RNA strands, peptidyl RNA and cofactors. Angew. Chem. Int. Ed. 2015, 54, 14564-14569.

    highlighted on: [ (Deutsch), (Englisch)]

    M. Jauker, H. Griesser, C. Richert, Spontane Bildung von RNA- RNA-Straengen, Peptidyl-RNA und Cofaktoren. Angew. Chem. 2015, 127, 14772-14777.

  16. M. Jauker, H. Griesser, C. Richert, Copying of RNA sequences without pre-activation. Angew. Chem. Int. Ed. 2015, 54, 14559-14563.

    highlighted on: []

    M. Jauker, H. Griesser, C. Richert, Kopieren von RNA-Sequenzen ohne Voraktivierung. Angew. Chem. 2015, 127, 14767-14771.

  17. S. Vollmer, C. Richert, Effect of preorganization on the affinity of synthetic DNA binding motifs for nucleotide ligands. Org. Biomol. Chem. 2015, 13, 5734 - 5742.

  18. A. Schwenger, W. Frey, C. Richert, Tetrakis(dimethoxyphenyl)adamantane (TDA) and its inclusion complexes in the crystalline state: A versatile carrier for small molecules. (inside back cover). Chem. Eur. J. 2015, 21, 8781-8789.

  19. A. Schwenger, H. Griesser, C. Richert, DNA-Based nanostructuring with branched oligonucleotide hybrids, in E. Stulz, G. Clever (eds.) DNA in Supramolecular Chemistry and Nanotechnology, John Wiley & Sons, Chichester, 2015, ISBN: 9781118696866.

  20. A. Schwenger, C. Gerlach, H. Griesser, C. Richert, Synthesis of eight-arm, branched oligonucleotide hybrids and studies on the limits of DNA-driven assembly. J. Org. Chem. 2014, 79, 11558-11566.

  21. C. Gerlach, B. Claasen, C. Richert, High fidelity recognition of RNA: Solution structure of an RNA-DNA hybrid duplex with a molecular cap. ChemBioChem, 2014, 15, 2584-2589.

    highlighted on: [ Wiley-VCH Hot Topics ]

  22. C. Kroener, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells. Angew. Chem. 2014, 126, 9352-9356; Angew. Chem. Int. Ed. 2014, 53, 9198-9202.
  23. highlighted on: [ press release by Angew. Chem | | | | innovations-report | news-medical ]

  24. M. Minuth, W. Frey, C. Richert, Improved synthesis of a salicylic aldehyde C-nucleoside for metallo base pairs via Heck reaction. Synlett, 2014, 10, 1438-1442.

  25. E. Kervio, B. Claasen, U.E. Steiner, C. Richert, The strength of the template effect attracting nucleotides to naked DNA. Nucleic Acids Res., 2014, 42, 7409-7420.

  26. M. Minuth, C. Richert, Kuenstliche Base zum Nachweis von DNA-Sequenzen. Spektrum Wissensch. 2014, 3, 19-21.

  27. R. Haug, M. Kramer, C. Richert, Three-pronged probes: High-affinity DNA binding with cap, beta-alanines and oligopyrrolamides (Communication). Chem. Eur. J. 2013, 19, 15822-15826.

  28. C. Kroener, A. Goeckel, W. Liu, C. Richert, Binding cofactors with triplex-based DNA motifs (Inside Cover). Chem. Eur. J. 2013, 19, 15879-15887.

  29. M. Minuth, C. Richert, A nucleobase analog that pairs strongly with adenine. Angew. Chem., 2013, 125, 11074-11077; Angew. Chem. Int. Ed., 2013, 52, 10874-10877.

    highlighted on: [ ]

    also highlighted on: [ Pressebox | | VBio | innovations-report | | idw | Analytik News ]

  30. A. Kaiser, C. Richert, Nucleotide-based copying of nucleic acid sequences without enzymes (Synopsis). J. Org. Chem. 2013, 78, 793-799.

  31. K. Leu, E. Kervio, B. Obermayer, R. M. Turk-MacLeod, C. Yuan, J.-M. Luevano Jr., E. Chen, U. Gerland, C. Richert, I. A. Chen, Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences. J. Am. Chem. Soc. 2013, 135, 354-366.

  32. H. Vogel, C. Gerlach, C. Richert, Reactions of Buffers in Cyanogen Bromide-Induced Ligations. Nucleosides Nucleotides Nucl. Acids, 2013, 32, 17-27.

  33. H. Said, V. Schueller, F. Eber, C. Wege, T. Liedl, C. Richert, M1.3 - A small scaffold for DNA origami, Nanoscale, 2013, 5, 284-290.

  34. H. Said, C. Guttroff, A. H. El-Sagheer, C. Richert, Two-step synthesis of a 5'-azidothymidine building block for the assembly of oligonucleotides for triazole-forming ligations. Synlett 2012, 23, 2923-2926.

  35. A. Kaiser, S. Spies, T. Lommel, C. Richert, Template-Directed Synthesis in 3'- and 5'-Direction with Reversible Termination. Angew. Chem. 2012, 124, 8424-8428; Angew. Chem. Int. Ed. 2012, 51, 8299-8303.(hot paper and back cover).

    Highlighted in: Arenz, C. Oligonukleotide (Trendbericht 2012). Nachr. Chem. 2013, 61, 284-286.
    Highlight by Michael Pirrung, in Faculty of 1000.
    Interview with Clemens by News Medical

    also highlighted on: [ | | | | | | News Medical | VBio | | | | ]

  36. S. Egetenmeyer, E. Geiger, C. Richert, Segmented hybridization probes: Modulating target affinity and base pairing selectivity. Biotechnologia, 2012, 93, 309-317.
    Link to the online version

  37. S. Egetenmeyer, C. Richert, Synthesis of oligodeoxynucleotides with 5'-caps binding RNA targets. Curr. Prot. Nucl. Acid Chem. 2012, 51:4.53.1–4.53.21.

  38. H. Vogel, C. Richert, Labeling small RNAs through chemical ligation at the 5'-terminus - enzyme-free or combined with enzymatic 3'-labeling. ChemBioChem 2012, 13, 1474-1482.

  39. A. Singh, M. Tolev, C. Schilling, S. Braese, H. Griesser, C. Richert, Solution-phase synthesis of branched DNA hybrids via H-phosphonate dimers. J. Org. Chem. 2012, 77, 2718-2728.

  40. H. Griesser, M. Tolev, A. Singh, T. Sabirov, C. Gerlach, C. Richert, Solution-phase synthesis of branched DNA hybrids based on dimer phosphoramidites and phenolic or nucleosidic cores. J. Org. Chem. 2012, 77, 2703-2717.

  41. R. Haug, C. Richert, A porphycene-DNA hybrid and its DNA-templated interactions with a porphyrin. J. Porphyrins Phthalocyanines 2012, 16, 545-555.

  42. R. Haug, H. Griesser, Th. Sabirov, C. Richert, DNA-Porphyrin hybrids as reaction centers for photosensitized ene reactions with singlet oxygen. J. Porphyrins Phthalocyanines 2012, 16, 488-498.

  43. C. Deck, H. Vogel, M. Jauker, C. Richert, Chemische Primerverlängerung - Technologie zur Sequenzabfrage und Potentiell Präbiotischer Prozess. GIT Lab. Fachz. 2011, (11), 778-780.

  44. C. Prestinari, C. Richert, Intrastrand locks increase duplex stability and base pairing selectivity. Chem. Comm. 2011, 47, 10824-10826.

  45. S. Egetenmeyer, C. Richert, A 5'-cap for DNA probes binding RNA target strands. Chem. Eur. J. 2011, 17, 11813-11827.

  46. C. Kroener, M. Roethlingshoefer, T. Lommel, A. Kaiser, S. Spies, E. Kervio, C. Richert, Nucleotide storage and incorporation via chemical primer extension. Collection Symp. Ser. 2011, 12, 236-239 (ISBN 978-80-86241-37-1).

  47. C. Deck, M. Jauker, C. Richert, Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA. Nature Chem. 2011, 3, 603-608.

    Highlight by Michael Yarus, in Faculty of 1000.
    Highlight by Niles Lehman and Eric j. Hayden, in ChemBioChem.

    also highlighted on: [ | | | | | | | | | ]

  48. C. Kroener, C. Richert, Ein Speicher für Nucleosidderivate. Patent application, AZ 102011 014 788.8.

  49. C. Kroener, M. Roethlingshoefer, C. Richert, Designed nucleotide binding motifs. J. Org. Chem. 2011, 76, 2933-2936.

  50. A. Singh, M. Tolev, M. Meng, K. Klenin, O. Plietzsch, C. I. Schilling, T. Muller, M. Nieger, S. Braese, W. Wenzel, C. Richert, Branched DNA that forms a solid at 95 °C. Angew. Chem. 2011, 123, 3285-3289; Angew. Chem. Int. Ed. 2011, 50, 3227-3231.

    Highlighted on: [ | | | |]

  51. K.J.C. Heimann, C. Richert, DNA-Mediated site-specific deposition of gold nanoparticles on silicon wafers. Nanoscale 2010, 2, 2579-2582.

  52. A. Kaiser, C. Richert, Azidomethyl 4-nitrophenyl carbonate - a reagent for the one-step introduction of the azidomethyloxycarbonyl (Azoc) protecting group. Synlett 2010, 2267-2270.

  53. E. Kervio, A. Hochgesand, U. Steiner, C. Richert, Templating efficiency of naked DNA. Proc. Natl. Acad. Sci. USA, 2010, 107 , 12074-12079.

    Highlighted on: [ | | | | | | |]

  54. K. Gießler, H. Griesser, D. Göhringer, T. Sabirov, C. Richert, Synthesis of 3'-BODIPY-labeled active esters of nucleotides and a chemical primer extension assay on beads. Eur. J. Org. Chem. 2010, 19 , 3611-3620.

  55. M. Röthlingshöfer, C. Richert, Chemical primer extension at submillimolar concentration of deoxynucleotides (featured article). J. Org. Chem. 2010, 75, 3945-3952. (cover) .

  56. K. Müller, S. Malik, C. Richert, Sequence-Specifically Addressable Hairpin DNA-SWCNT Complexes for Nanoconstruction. ACS Nano 2010, 4, 649-656.

  57. C. Richert, M. Meng, A. Singh, Designed DNA crystals: Assembling triangles with short sticky ends (Highlight). Small 2009, 5, 2782-2783.

  58. K. Müller, C. Richert, The Unlikely Surfactant: DNA as a Ligand for Single-Walled Carbon Nanotubes. In: "Carbon Nanotubes", Marulanda, J. M. (ed.), INTECH, Vienna/Vukovar: 2010, ISBN 978-953-307-054-4, page 749-765.

  59. O. Plietzsch, C. I. Schilling, M. Tolev, M. Nieger, C. Richert, Th. Muller, S. Braese, Four-fold Click reactions: Generation of tetrahedral methane- and adamantane-based building blocks for higher molecular assemblies. Org. Biomol. Chem. 2009, 7, 4734-4743.

  60. A. Patra, C. Richert, High fidelity base pairing at the 3'-terminus. J. Am. Chem. Soc. 2009, 131 , 12671-12681.

  61. M. Meng, C. Ahlborn, M. Bauer, O. Plietzsch, S. A. Soomro, A. Singh, T. Muller, W. Wenzel, S. Bräse, C. Richert, Two base pair duplexes suffice to build a novel material. ChemBioChem 2009, 10 , 1335-1339.
  62. Highlighted on: [ | | | | | | | | ]

  63. R. Eisenhuth, C. Richert, Convenient syntheses of 3'-amino-2',3'-dideoxynucleosides, their 5'-monophosphates, and 3'-aminoterminal oligodeoxynucleotide primers (Featured Article). J. Org. Chem. 2009, 74, 26-37.

  64. M. Printz, C. Richert, Pyrenylmethyldeoxyadenosine: A 3'-cap for universal DNA hybridization probes. Chem. Eur. J. 2009, 15, 3390-3402.

  65. J. A. Rojas Stuetz, E. Kervio, C. Deck, C. Richert, Chemical primer extension: individual steps of spontaneous replication. In: P. Herdewijn, M. V. Kisakürek (eds.) Origin of Life - Chemical Approach. VHCA/Wiley-VCH, Zurich: 2008, pages 373-391.

  66. C. Richert, M. Meng, K. Müller, K. Heimann, The third dimension: DNA-driven formation of nanoparticle crystals (Highlight). Small 2008, 4, 1040-1042.

  67. M. Röthlingshöfer, E. Kervio, T. Lommel, U. Plutowski, A. Hochgesand, C. Richert, Chemical primer extension in seconds. Angew. Chem. 2008, 120, 6154-6157; Angew. Chem. Int. Ed. 2008, 47, 6065-606.

  68. F. Eberle, K. Giessler, C. Deck, K. Heeg, M. Peter, C. Richert, A. H. Dalpke, Modifications in siRNA that separate immunostimulation from RNA interference. J. Immunol. 2008, 180, 3229-3237.

  69. K. Siegmund, C. Ahlborn, C. Richert, ChipCheckII - Predicting binding curves for multiple analyte strands on small DNA microarrays. Nucleosides Nucleotides Nucl. Acids, 2008, 27, 376-388.

  70. S. R. Vogel, K. Müller, U. Plutowski, M. M. Kappes, C. Richert, DNA-carbon nanotube interactions and nanostructuring based on DNA. Phys. Stat. Sol. B 2007, 244, 4026-4029.

  71. C. Ahlborn, K. Siegmund, C. Richert, Isostable DNA. J. Am. Chem. Soc. 2007, 129, 15218-15232.
  72. See also:
    Highlight by S.K. Silverman, in Faculty of 1000 Biology.
    Highlighted in: Nature Methods 2008, 5, 123.

  73. U. Plutowski, S. R. Vogel, M. Bauer, C. Deck, M. Pankratz, C. Richert, Enzyme-free interrogation of RNA sites via primers and oligonucleotides 3'-linked to gold-surfaces. Org. Lett. 2007, 9, 2187-2190.

  74. S.R. Vogel, C. Richert, Adenosine residues in the template do not block spontaneous replication steps of RNA. Chem. Comm. 2007, 1896-1898.

    Highlighted in: M. Spencelayh, RNA on ice. RSC Chemical Biolology, 2007, 2, B41 (cover story).

  75. G. He, A. Patra, K. Siegmund, M. Peter, K. Heeg, A. Dalpke, C. Richert, Immunostimulatory CpG oligonucleotides form defined three-dimensional structures: results from an NMR study. ChemMedChem 2007, 2, 549-560.

  76. U. Plutowski, S.S. Jester, S. Lenhert, M.M. Kappes, C. Richert, DNA-based self-sorting of nanoparticles on gold surfaces. Adv. Mat. 2007, 19, 1951-1956.

    Highlighted in: M. Berger, The long road to molecular electronics could be paved with DNA. Nanowerk Spotlight, 2007, August 6.

  77. M. Printz, C. Richert, Optimizing the stacking moiety and linker of 2'-acylamido caps of DNA duplexes with 3'-terminal adenine residues. J. Combin. Chem. 2007, 9, 306-320.

  78. J. A. Rojas Stütz, E. Kervio, C. Deck, C. Richert, Chemical primer extension - individual steps of spontaneous replication (Account). Chem. Biodiv. 2007, 4, 784-802.

  79. L. Zhang, H. Zhu, M.C. Sajimon, J.A. Rojas Stütz, K. Siegmund, C. Richert, V. Shafirovich, F.D. Lewis, Stabilization of DNA hairpins by stilbene capping of the terminal base pair. J. Chin. Chem. Soc. 2006, 53, 1501-1507.

  80. C. Richert, P. Grünefeld, Synthesis and properties of oligonucleotides with acylamido substituents. (Account) Synlett 2007, 1-18.

  81. S. R. Vogel, M. M. Kappes, F. Hennrich, C. Richert, An unexpected new optimum in the structure space of DNA solubilizing single-walled carbon nanotubes. Chem. Eur. J. 2007, 13, 1815-1820.

  82. N. Griesang, K. Giessler, T. Lommel, C. Richert, Four color, enzyme-free interrogation of DNA sequences with chemically activated, 3'-fluorophore-labeled nucleotides. Angew. Chem. 2006, 118, 6290-6294; Angew. Chem. Int. Ed. 2006, 45 , 6144-6148.

  83. J. A. Rojas Stütz, C. Ahlborn, C. Richert, Ansätze zu "High Fidelity DNA-Microarrays". Bioforum 2006, 29 (5), 32-34.

  84. S. Malik, S. Vogel, H. Rösner, K. Arnold, F. Hennrich, A.-K. Köhler, C. Richert, M.M. Kappes, Physical chemical characterisation of DNA-SWNT suspensions and associated composites. Comp. Sci. Tech. 2007, 67, 916-921.

  85. P. Gruenefeld, C. Richert, Effect of microwave irradiation on phosphoramidite couplings on controlled pore glass. Nucleosides Nucleotides Nucl. Acids 2006, 25, 815-821.

  86. P. Baumhof, N. Griesang, M. Bächle, C. Richert, Synthesis of oligonucleotides with 3'-terminal 5-(3-acylamidopropargyl)-3'-amino-2',3'-dideoxyuridine residues and their reactivity in single nucleotide steps of chemical replication. J. Org. Chem. 2006, 71, 1060-1067.

  87. J. A. Rojas Stütz, C. Richert, Tuning the reaction site for enzyme-free primer extension reactions through small molecule substituents. Chem. Eur. J. 2006, 12, 2472-2481.

  88. S.R. Vogel, C. Deck, C. Richert, Accelerating chemical replication steps of RNA involving activated ribonucleotides and downstream-binding elements. Chem. Comm. 2005, 4922-4924.
    For news highlights on this paper, see:
    Chemical Science
    Hahn, U. Raschere enzymfreie RNA-Replikationsschritte. Nachr. Chem. 2005, 53, 1109.

  89. K. Siegmund, S. Maheshwary, S. Narayanan, W. Connors, M. Riedrich, M. Printz, C. Richert, Molecular details of quinolone-DNA interactions: Solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. Nucleic Acids Res., 2005, 33, 4838-4848.

  90. P. Hagenbuch, E. Kervio, A. Hochgesand, U. Plutowski, C. Richert, Chemical primer extension: efficiently determining single nucleotides in DNA. Angew. Chem., 2005, 117, 6746-6750; Angew. Chem. Int. Ed. 2005, 44, 6588-6592.
    (Highlighted in: H.-A. Wagenknecht, Nachr. Chem. 2006, 54, 245-246.)

  91. S. Al-Rawi, C. Ahlborn, C. Richert, 3'-Immobilized probes with 2'-caps: synthesis of oligonucleotides with 2'-N-methyl-2'-(anthraquinone carboxamido)uridine residues. Org. Lett. 2005, 7, 1569-1572.

  92. N. Griesang, E. Kervio, C. Richert, Linker-free fluorophore-labeled oligonucleotides: synthesis of 3'-fluoresceinylthymidine building blocks and their coupling reactions. Synthesis 2005, 2327-2334.

  93. T. Ernst, C. Richert, A reactivity test for HBTU-activated carboxylic acids with low reactivity and competitive coupling of N-methylpyrrole derivatives. Synlett 2005, 411-416.

  94. U. Plutowski, C. Richert, A direct glimpse of cross-hybridization: background-passified microarrays that allow mass spectrometric detection of captured oligonucleotides. Angew. Chem. 2005, 117, 627-631; Angew. Chem.Int.Ed. 2005, 44, 621-625.

  95. J. Tuma, R. Paulini, J. A. Rojas Stütz, C. Richert, How much pi-stacking do DNA termini seek? Solution structure of a self-complementary DNA hexamer with trimethoxystilbenes capping the terminal base pairs. Biochemistry 2004, 43, 15680-15687.

  96. P. Grünefeld, C. Richert, Synthesis of a 1'-aminomethylthymidine and oligodeoxyribonucleotides with 1'-acylamidomethylthymidine residues. J. Org. Chem. 2004, 69, 7543-7551.

  97. S. Narayanan, J. Gall, C. Richert, Clamping down on weak terminal base pairs: oligonucleotides with molecular caps as fidelity-enhancing elements at the 5'- and 3'-terminal residues. Nucleic Acids Res. 2004, 32, 2901-2911.

  98. C. Richert, M. Pankratz, DNA-Chips: Kleine Plättchen, mit denen sich die Aktivität des Genoms verfolgen lässt. Fridericiana 2004, 62, 19-32.

  99. T. Kottysch, C. Ahlborn, F. Brotzel, C. Richert, Stabilizing or destabilizing oligodeoxynucleotide duplexes containing single 2'-deoxyuridine residues with 5-alkynyl substituents. Chem. Eur. J. 2004, 10, 4017-4028.

  100. Z. Dogan, R. Paulini, J.A. Rojas Stütz, S. Narayanan, C. Richert, 5'-Tethered stilbene derivatives as fidelity- and affinity-enhancing modulators of DNA duplex stability. J. Am. Chem. Soc. 2004, 126, 4762-4763.

  101. J.A. Rojas Stuetz, C. Richert, Synthesis of a formamidine-protected 5'-amino-2',5'-dideoxyguanosine phosphoramidite and preparation of 5'-acylamidooligonucleotides. Tetrahedron Lett. 2004, 45, 509-513.

  102. S. Narayanan, A.H. Dalpke, K.H. Siegmund, K. Heeg, C. Richert, CpG Oligonucleotides with modified termini and nicked dumbbell structure show enhanced immunostimulatory activity.J. Med. Chem. 2003, 46, 5031-5044.

  103. J. Tuma, C. Richert, Solution structure of a steroid-DNA complex with cholic acid residues sealing the termini of a Watson-Crick duplex. Biochemistry 2003, 42, 8957-8965.

  104. K. Siegmund, U.E. Steiner, C. Richert, ChipCheck - A program predicting total hybridization equilibria for DNA binding to small oligonucleotide microarrays. J. Chem. Inf. Comp. Sci. 2003, 43, 2153-2162.

  105. W.H. Connors, S. Narayanan, O.P. Kryatova, C. Richert, Synthesis of oligonucleotides with a 2'-cap at the 3'-terminus via reversed phosphoramidites. Org. Lett. 2003, 5, 247-250.

  106. K.L. Dombi, U.E. Steiner, C. Richert, Rapidly Measuring Reactivities of Carboxylic Acids to Generate Equireactive Building Block Mixtures: A Spectrometric Assay. J. Combin. Chem. 2003, 5, 45-60.

  107. J. L. Weemhoff, L. L. Von Moltke, C. Richert, L. M. Hesse, J. S. Harmatz, D. J. Greenblatt, Apparent mechanism-based inhibition of human CYP3A in vitro by lopinavir. J. Pharm. Pharmacol. 2003, 55, 381-386.

  108. N. Griesang, C. Richert, Oligonucleotides Containing a Nucleotide Analog with an Ethynylfluorobenzene as Nucleobase Surrogate. Tetrahedron Lett. 2002, 43, 8755-8758.

  109. K.L. Dombi, N. Griesang, C. Richert, Oligonucleotide arrays from aldehyde-bearing glass with coated background. Synthesis 2002, 816-824.

  110. J. Tuma, W.H. Connors, D.H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on Termini of DNA-Duplexes. J. Am. Chem. Soc. 2002, 124, 4236-4246.

  111. J.A. Rojas Stütz, C. Richert, A Steroid Cap Adjusts the Selectivity and Accelerates the Rates of Non-Enzymatic Single Nucleotide Extensions of an Oligonucleotide. J. Am. Chem. Soc. 2001, 123, 12718-12719.

  112. C.N. Tetzlaff, C. Richert, Synthesis and Hydrolytic Stability of 5'-Aminoacylated Oligouridylic Acids, Tetrahedron Lett. 2001, 42, 5681-5684.

  113. A.A. Mokhir, W.H. Connors, C. Richert, Synthesis and Monitored Selection of Nucleotide Surrogates for Binding T:A Base Pairs in Homopurine-Homopyrimidine DNA Triple Helices. Nucleic Acids Res.2001, 29, 3674-3684.

  114. A.A. Mokhir, C.N. Tetzlaff, S. Herzberger, A. Mosbacher, C. Richert, Monitored selection of DNA-hybrids forming duplexes with capped terminal C:G base pairs. J. Combin. Chem. 2001, 3, 374-386.

  115. C. Richert, Thoughts of a Nucleic Acid Chemist Who Finds Himself in the Postgenomic Era. Chem. & Engin. News 2001, March 26, 257.

  116. O.P. Kryatova, W.H. Connors, C.F. Bleczinski, A.A. Mokhir, C. Richert, A 2'-acylamido cap that increases the stability of oligonucleotide duplexes. Org. Lett.2001, 3, 987-990.

  117. D.A. Sarracino, C. Richert, Synthesis and Nuclease Stability of Trilysyl Dendrimer-Oligodeoxyribonucleotide Hybrids. Bioorg. Med. Chem. Lett. 2001, 11, 1733-1736.

  118. K.L. Dombi, C. Richert, Relative Reactivities of Activated Carboxylic Acids in Amide-Forming Reactions Employed for the Synthesis of Tetraphenylporphyrin Libraries, Molecules, 2000, 5, 1265-1280.

  119. A.A. Mokhir, C. Richert, Synthesis and Monitored Selection of 5'-Nucleobase-Capped Oligodeoxyribonucleotides, Nucleic Acids Res. 2000, 28, 4254-4265.

  120. J. Stoerker, J. Mayo, C.N. Tetzlaff, D.A. Sarracino, I. Schwope, C. Richert, Rapid genotyping via MALDI-monitored nuclease selection from probe libraries, Nature Biotechn., 2000, 18, 1213-1216.

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  121. C.F. Bleczinski, C. Richert, Solid-Phase Synthesis of Cyclic Peptide-DNA Hybrids, Org. Lett., 2000, 2, 1697-1700.

  122. R.K. Altman, I. Schwope, D.A. Sarracino, C.N. Tetzlaff, C.F. Bleczinski, C. Richert, Selection of modified oligonucleotides with increased target affinity via MALDI-monitored nuclease survival assays , J. Combin. Chem., 1999, 1, 493-508.

  123. W.C. Ho, C. Steinbeck, C. Richert, Solution Structure of the Aminoacyl-Capped Oligodeoxyribonucleotide Duplex (W-TGCGCAC)2 , Biochemistry, 1999, 38, 12597-12606.

  124. C.F. Bleczinski, C. Richert, Steroid-DNA interactions increasing stability, sequence-selectivity, DNA/RNA discrimination, and hypochromicity of oligonucleotide duplexes, J. Am. Chem. Soc., 1999, 121, 10889-10894.

  125. I. Schwope, C.F. Bleczinski, and C. Richert, Synthesis of 3',5'-Dipeptidyl Oligonucleotides, J. Org. Chem., 1999, 64, 4749-4761.

  126. D.L. Daniels, C. Richert, One-pot synthesis of L-felinine, Tetrahedron Lett., 1999, 40, 4463-4465.

  127. M.D. Simon and C. Richert, Synthesis and Selection of Aminoacyl- and Dipeptidyl-Tetraphenylporphyrins: Toward Target-Specific Nucleic-Acid Ligands, Nucleus 1999 (5), 23-28.

  128. C. F. Bleczinski, C. Richert, Monitoring the hybridization of the components of oligonucleotide mixtures to immobilized DNA via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Rapid Comm. Mass Spectrom., 1998, 12, 1737-1743.

  129. C. Steinbeck, C. Richert, The Role of Ionic Backbones in RNA Structure: An Unusually Stable non-Watson-Crick Duplex of a Non-Ionic Analog in an Apolar Medium. J. Am. Chem. Soc., 1998, 120, 11576-11580.

  130. D.A. Sarracino, J.A. Steinberg, M.T. Vergo, G.F. Woodworth, C.N. Tetzlaff, C. Richert, 5'-Peptidyl Substituents Allow a Tuning of the Affinity of Oligodeoxyribonucleotides for RNA. Bioorg. Med. Chem. Lett., 1998, 8, 2511-2516.

  131. C.N. Tetzlaff, I. Schwope, C.F. Bleczinski, J.A. Steinberg, C. Richert, A convenient synthesis of 5'-amino-5'-deoxythymidine and preparation of peptide-DNA hybrids. Tetrahedron Lett., 1998, 39, 4215-4218.

  132. K. Berlin, R.K. Jain, C. Richert, Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins. Biotechn. Bioengin.: Combin. Chem., 1998, 61, 107-118.

  133. K. Berlin, R.K. Jain, M.D. Simon, C. Richert, A porphyrin embedded in DNA. J. Org. Chem, 1998, 63, 1527-1535.

  134. R.K. Jain, D.A. Sarracino, and C.Richert, A tetraphenylporphyrin-peptide hybrid with high affinity for single-stranded DNA. Chem. Comm., 1998, 423-424.

  135. C. Steinbeck, K. Berlin, C. Richert, MASP - a program predicting mass spectra of combinatorial libraries. J. Chem. Inf. Comput. Sci., 1997, 37, 449-457.

  136. K. Berlin, R.K. Jain, C. Tetzlaff, C. Steinbeck, C. Richert, Spectrometrically monitored selection experiments: quantitative laser desorption mass spectrometry of small chemical libraries. Chemistry & Biology 1997, 4, 63-77; 1997, 4, 237- 238.

  137. Abels, C.; Szeimies, R.M.; Steinbach, P.; Richert, C.; Goetz, A.E. Targeting of the tumor microcirculation by photodynamic therapy with a synthetic porphycene. J. Photochem. Photobiol. B., 1997, 40, 305-312.

  138. D. Sarracino, C. Richert, Quantitative MALDI-TOF Spectrometry of Oligonucleotides and a Nuclease Assay. Bioorg. Med. Chem. Lett., 1996, 6, 2543-2548.

  139. D.K. Baeschlin, B. Hyrup, S.A. Benner, C. Richert, Chimera of Dimethylenesulfone, Methylsulfide, and Methylsulfoxide Linked Ribonucleotides and DNA. J. Org. Chem., 1996, 61, 7620-7626.

  140. C. Richert, A.L. Roughton, S.A. Benner, Non-ionic Analogs of RNA with Dimethylenesulfone Bridges. J. Am. Chem. Soc., 1996, 118, 4518-4531.

  141. D.K. Baeschlin, M. Daube, M.O. Blaettler, S.A. Benner, C. Richert, Four Step Synthesis of a 5'-Deoxy-5'-Iodomethylthymidine. Tetrahedron Lett., 1996, 37, 1591-1592.

  142. M. Dellian, C. Richert, F. Gamarra, A.E. Goetz, Photodynamic eradication of amelanotic melanoma of the hamster with fast acting photosensitizers. Int. J. Cancer, 1996, 65, 246-248.

  143. B. Hyrup, C. Richert, T. Schulte-Herbrueggen, S.A. Benner, M. Egli, X-ray crystal structure of a dimethylene sulfone-bridged ribonucleotide dimer in a single-stranded state. Nucleic Acids Res., 1995, 23, 2427-2433.

  144. C. Richert, J.M. Wessels, M. Mueller, M. Kisters, T. Benninghaus, A.E. Goetz, Photodynamic antitumor agents: b-methoxyethyl groups give access to functionalized porphycenes and enhance cellular uptake and activity. J. Med. Chem. 1994, 37, 2797-2807.

  145. M. Leunig, C. Richert, F. Gamarra, W. Lumper, E. Vogel, D. Jocham, A.E. Goetz, Tumour localization kinetics of photofrin and three synthetic porphyrinoids in an amelanotic melanoma of the hamster. Br. J. Cancer, 1993, 68, 225-234.

  146. C. Richert, A longtime stable liposome formulation for porphyrinoid photosensitizers. J. Photochem. Photobiol. B. 1993, 19, 67-69.

  147. Leunig, M.; Richert, C.; Gamarra, F.; Lumper, W.; Vogel, E.; Jocham, D.; Goetz, A.E. Analysis of tumor-localization of 3 synthetic porphyrinoids and photofrin -II in an amelanotic melanoma. FASEB J., 1993, 7, A892-A892.

  148. T. Sassy, C. Richert, R. Baumgartner, D. Jocham, E. Unsoeld, Comparative study of the photodynamic effects of porphycenes and Photofrin II on SSK2-fibrosarcoma of mice. Lasers Med. Sci., 1992, 7, 255.

  149. F. Gamarra, F. Yuan, A.E. Goetz, M. Leunig, C. Richert, R.K. Jain, K. Messmer, Monitoring extravascular transport of porphycenes. In P. Spinelli, M. Dal Fante, R. Marchesini (Eds.) "Photodynamic therapy and biomedical lasers", Elsevier, Amsterdam, Excerpta Med. 1992, 1011, 706-709.

  150. C. Richert, F. Gamarra, P. Heil, D. Jocham, E. Vogel, A.E. Goetz, Etherporphycenes: Non-ionic polar sidechains accelerate cell- and serumkinetics and enhance cellular uptake of porphyrinoids. In P. Spinelli, M. Dal Fante, R. Marchesini (Eds.) "Photo dynamic therapy and biomedical lasers", Elsevier, Amsterdam, Excerpta Med., 1992, 1011, 702-705.

  151. M. Dellian, C. Richert, F. Gamarra, A.E. Goetz, Tumor growth following PDT with functionalized porphycenes and photofrin II. In P. Spinelli, M. Dal Fante, R. Marchesini (Eds.) "Photodynamic therapy and biomedical lasers", Elsevier, Amsterdam, Excerpta Med., 1992, 1011, 467-469.

  152. T. Sassy, C. Richert, R. Baumgartner, D. Jocham, E. Unsoeld, Comparative study of the photodynamic effects of porphycenes and Photofrin II on SSK2-fibrosarcoma of mice. Las. Med. Sci., 1992, 7, 255.

  153. E. Vogel, C. Richert, T. Benninghaus, M. Mueller, A.D. Cross, "Porphycene compounds for photodynamic therapy", US Patent No. 5,409,900 (European patent application No 92913690).

Supporting Information

Supporting information for publications where publishers do not provide supporting information files online.

  1. F. Eberle, K. Giessler, C. Deck, K. Heeg, M. Peter, C. Richert, A. H. Dalpke, Modifications in siRNA that separate immunostimulation from RNA interference. J. Immunol. 2008, 180, 3229-3237.
    [ Supporting Information ]

  2. K. Siegmund, C. Ahlborn, C. Richert, ChipCheckII - Predicting Binding Curves for Multiple Analyte Strands on Small DNA Microarrays. Nucleosides Nucleotides Nucl. Acids 2008, 27, 376-388.
    [ Supporting Information ]